![]() MRI showed a 12 cm tumor in the right adrenal. The patient had no clinical features of cortisol excess. She presented high estradiol (818 pg/mL – 25 times above upper normal limit for postmenopausal women) and testosterone (158 ng/dL – 2 times above upper normal limit) levels and no suppression of cortisol after overnight 1 mg dexamethasone test (12.5 µg/dL normal reference value: < 1.8 µg/dL). We report the case of a 58-year-old woman who presented with bilateral breast enlargement and postmenopausal genital bleeding. ![]() Estrogen-secreting adrenocortical carcinomas are extremely rare, especially in women, tend to be larger and have worse prognosis compared with other types of ACCs. Adrenocortical carcinoma (ACC) is a malignant disorder with rapid evolution and severe prognosis in adults and most produce cortisol and androgen.
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